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One of the most important discoveries of this decade. Endothelial dysfunction and disorders of clotting. One of the most important discoveries of this decade as we start to think about long covid. We are starting to see a majority of LC patients, in many studies more than 90%, are starting to show evidence of vascular pathology. SARS-CoV-2 binds to ACE-2 and you have the most in your blood vessels.
https://www.youtube.com/embed/vo7fZyLAiCs?start=1453&end=1691
Blood tests: VEGF endothelial marker is it high? CD40 Ligand platelet marker is it high?
https://www.youtube.com/embed//1MQEqfmYbu0?start=447&end=479
There are three ways to look for damage: Fluorescent microscope test, Endopat testing, blood tests for endothelial and platelet markers
https://www.youtube.com/embed/1MQEqfmYbu0?start=509&end=528
At the same time you form a clot the body starts breaking down the clot. The balance between clotting and breakdown is important. Since the endothelial damage is so widespread that the body’s ability to maintain normal clotting physiology fails. So you have many areas where platelets get activated and they form these clumps and form micro clots, and together with endothelial damage, causes a problem with oxygen transfer.
https://www.youtube.com/embed/1MQEqfmYbu0?start=1054&end=1130
What to expect from anticoagulant therapy?? Short covid 3-4 months anti coag may have full recovery. Long covid 4-6 months and some symptoms may not go away
https://www.youtube.com/embed/1MQEqfmYbu0?start=1792&end=1840
Microclots in skeletal muscles. Amyloid containing deposits in skeletal muscles, but not inside capillaries
https://www.youtube.com/embed/uQiv0zSveA8?start=1198&end=1390
Skeletal muscle – necrotic fiber in the skeletal muscle. Infiltration of immune cells T-cells and macrophages and amyloid microclots into skeletal muscles
https://www.youtube.com/embed/uQiv0zSveA8?start=1397&end=1498
Thrombotic endotheliatis and microclots, immune dysfunction and autoantibodies, viral persistence, cytokine dysregulation, muscle involvement, hormone dysregulation, subtypes of Long COVID as a result of key pathologies driving the symptoms.
https://www.youtube.com/embed/BZoNhDYciQk?start=224&end=344
Endothelial damage can cause huge amounts of damage to your body and organs because this is the way oxygen is delivered to your body to your organs to your brain. The blood brain barrier is nothingĀ more than an endothelial layer. Platelet activation when they interact with inflammatory molecules, fibrinogen can turn pathological in the presence of inflammatory molecules
https://www.youtube.com/embed/BZoNhDYciQk